AnticoagulantInjectionManufacturs DESCRIPTION The active ingredient in AVATROMBOPAG MALEATE is avatrombopag maleate, a thrombopoietin receptor agonist. The chemical name of avatrombopag maleate is 4 piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2 thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-, (2Z)-2-butenedioate (1:1). It has the molecular formula C29H34Cl2N6O3S2 路 C4H4O4. The molecular weight is 765.73. The structural formula is: The aqueous solubility of avatrombopag maleate at various pH levels indicates that the drug substance is practically insoluble at pH 1 to 11. AVATROMBOPAG MALEATE is provided as an immediate-release tablet. Each AVATROMBOPAG MALEATE tablet contains 20 mg avatrombopag (equivalent to 23.6 mg of avatrombopag maleate) and the following inactive ingredients: lactose monohydrate, colloidal silicon dioxide, crospovidone, magnesium stearate and microcrystalline cellulose. Coating film: polyvinyl alcohol, talc, polyethylene glycol, titanium dioxide and ferric oxide yellow. Mechanism of Action Avatrombopag is an orally bioavailable, small molecule TPO receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets. Avatrombopag does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production. Pharmacodynamics Platelet Response AVATROMBOPAG MALEATE administered to adult patients resulted in dose- and exposure-dependent elevations in platelet counts. The onset of the platelet count increase was observed within 3 to 5 days of the start of treatment, with peak effect after 10 to 13 days. Post treatment, platelet counts decreased gradually, returning to near baseline values. Name: Avatrombopag maleate Avatrombopag maleate is a prescription medicine used to treat the symptoms of Thrombocytopenia (lack of platelets in the blood). Specification 20mg Indications Treatment Of Thrombocytopenia In Patients With Chronic Liver Disease (CLD) Avatrombopag maleate is indicated for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure. Treatment Of Thrombocytopenia In Patients With Chronic Immune Thrombocytopenia (ITP) Avatrombopag maleate is indicated for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment. Hangzhou Jiuyuan is a top-biotech joint venture specializing in the research, development, manufacture, and marketing of pharmaceuticals based on gene engineering and biochemical technology since 1993. It has gene engineering workshops, injection workshops, pharmaceutical API workshops, and other sections including the quality management department, warehouse, engineering department, etc., all of which are built according to GMP requirements. Jiuyuan is equipped with advanced production and analysis instruments like chromatography systems, HPLC, and capillary electrophoresis. We offer high-quality products and comprehensive sales services, please contact us. Corporate Mission Take Gene Engineering as Orientation Render Top Service to Human Heal Company Honor Zhejiang province per mu benefit leading enterprises Gene-engineering New Drug RD Technology and Service Sub-platform Provincial Post-doctoral Scientific Research Working Center Excellent industrial products in Zhejiang Province Hangzhou Academician Expert Working Center Hangzhou Top Ten New High-tech Enterprise Zhejiang Green Enterprise What is your advantage compared with your competitors? (1). Qualified Manufacturer (2). Reliable Quality Control (3). Competitive Price (4). High-Efficiency working (24*7hours) (5). One-Stop Service Our Services 1. Good knowledge on different market can meet special requirements. 2. Real manufacturer with our own factory located in China 3. Strong professional technical team ensure to produce the top quality products. 4. Special cost control system ensure to provide the most favorable price. 5. Rich experience on drug.AnticoagulantInjectionManufacturs website:http://www.jiuyuangene.net/finished-dosage-form/anticoagulant-injection/